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[抗甲型肝炎病毒抗体行为观察(作者译)]

[Observations on the behaviour of anti-HAV antibodies (author's transl)].

作者信息

Cenciotti L, Abbondanza G C

出版信息

Quad Sclavo Diagn. 1978 Dec;14(4):458-67.

PMID:231796
Abstract

The behaviour of anti-HAV antibodies was studied in the following conditions: a) a sample group of 2645 subjects from a healthy population; b) a group of 32 subjects with previous HB-Ag negative viral hepatitis; c) 12 cases of acute virus A hepatitis; d) a group of 18 anti-HAV positive women at the end of their pregnancies the antibodies were thus also studied in the funicular blood and in the newborn babies. The results showed: a) high reactivity (78%) of the healthy population to anti-HAV's; b) the possibility of an a posteriori diagnosis of virus A hepatitis in the presence of serology, negative for B type hepatitis, and positive for the anti-HAV's but with a titre higher than 1:200; c) the possibility of a serological diagnosis of acute virus A hepatitis in the presence of serology, negative for B type hepatitis and positive for the anti-HAV's with high and progressively increasing titre; d) the possibility of anti-HAV antibodies passing from mother to foetus, and the rapid elimination of the antibodies by the newborn baby within a month of his birth.

摘要

在以下情况下研究了抗甲型肝炎病毒(anti-HAV)抗体的行为:a)来自健康人群的2645名受试者的样本组;b)一组先前乙肝表面抗原(HB-Ag)阴性的病毒性肝炎患者,共32例;c)12例急性甲型肝炎病例;d)一组18名在妊娠末期抗-HAV呈阳性的女性,还对其脐血和新生儿的抗体进行了研究。结果显示:a)健康人群对抗-HAV的高反应性(78%);b)在乙型肝炎血清学检测为阴性、抗-HAV检测为阳性且滴度高于1:200的情况下,有可能对甲型肝炎进行回顾性诊断;c)在乙型肝炎血清学检测为阴性、抗-HAV检测为阳性且滴度高且逐渐升高的情况下,有可能对急性甲型肝炎进行血清学诊断;d)抗-HAV抗体有可能从母亲传给胎儿,且新生儿在出生后一个月内会迅速清除这些抗体。

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