Sauret J, Casán P
Med Clin (Barc). 1980 Mar 25;74(6):235-8.
Gastroesophageal diseases with reflux can cause numerous pulmonary complications (bronchospasm crisis, bronchitis, pneumonias, lung abscesses). These manifestations are very frequent in the hiatal hernias and in some series have reached up to 46 percent of the cases studied. Recently it has been suggested that microaspirations, repeated over a long period of time, may cause an alteration of the pulmonary interstitium and the consecutive development of a clinical and roentgenologic picture similar to pulmonary fibrosis. The aspirations are produced more frequently at night, favoured by the lying down position and because of it the patients present attacks of nocturnal cough. In this paper, two patients who presented the association of pulmonary fibrosis and hiatal hernia with esophageal relux are described. The first case was diagnosed early; he had minimal radiographic anomalies and the disappearance of the respiratory symptomatology was achieved by means of the medical treatment of the esophageal reflux. The second case was in a very advanced stage with severe respiratory insufficiency and gastrointestinal manifestations of many years' evolution. Both patients had been diagnosed as having idiopathic pulmonary fibrosis. Although there is no experimental proof of the "reflux-fibrosis" theory, we think that this possibility should be kept in mind before diagnosing the interstitial pulmonary pattern as idiopathic, especially in the cases of only slight radiographic and functional involvement susceptible to improvement with correction of the esophageal reflux.
伴有反流的胃食管疾病可引发多种肺部并发症(支气管痉挛危象、支气管炎、肺炎、肺脓肿)。这些表现在食管裂孔疝中非常常见,在某些系列研究中,在所研究的病例中发生率高达46%。最近有人提出,长期反复的微量误吸可能导致肺间质改变,并继而出现类似于肺纤维化的临床和影像学表现。误吸在夜间更频繁发生,平躺姿势会促使其发生,因此患者会出现夜间咳嗽发作。本文描述了两名患有肺纤维化且伴有食管裂孔疝和食管反流的患者。第一例患者诊断较早;其影像学异常轻微,通过食管反流的药物治疗,呼吸道症状消失。第二例患者处于非常晚期,有严重的呼吸功能不全以及多年演变而来的胃肠道表现。两名患者均曾被诊断为特发性肺纤维化。尽管“反流 - 纤维化”理论尚无实验证据,但我们认为,在将间质性肺疾病模式诊断为特发性之前,尤其是在仅存在轻微影像学和功能受累且通过纠正食管反流可能改善的情况下,应考虑这种可能性。