Anderson M C, Hartley R B
Obstet Gynecol. 1980 May;55(5):546-50.
Knowledge of the frequency and extent of crypt involvement by cervical intraepithelial neoplasia (CIN) is important when treatment by electrodiathermy, cryosurgery, or the laser is considered. Three hundred forty-three therapeutic cone biopsies carried out at The Samaritan Hospital for Women, London, have been reviewed histologically. Measurements were made of the deepest crypt in each specimen and of the deepest crypt that contained CIN. The mean depth of involved crypts was 1.24 mm, and the mean depth of uninvolved crypts was 3.38 mm. Thus, destruction of tissue to a depth of 2.92 mm (mean + 1.96 SD) would eradicate all involved crypts in 95% of patients, whereas destruction to a depth of 3.80 mm would eradicate 99.7% (mean + 3 SD). There is also an increase in the depth of crypt involvement with increasing age, but the differences between the age groups are not statistically significant.
在考虑采用透热疗法、冷冻手术或激光进行治疗时，了解宫颈上皮内瘤变（CIN）累及腺管的频率和范围很重要。对伦敦撒玛利亚妇女医院进行的343例治疗性锥形活检进行了组织学检查。测量了每个标本中最深的腺管以及含有CIN的最深腺管。累及腺管的平均深度为1.24mm，未累及腺管的平均深度为3.38mm。因此，对组织进行2.92mm深度（均值+1.96标准差）的破坏将在95%的患者中根除所有受累腺管，而对3.80mm深度的破坏将根除99.7%（均值+3标准差）。随着年龄的增长，腺管受累深度也会增加，但各年龄组之间的差异无统计学意义。
