Rattray C, DaCosta V, Chatoor J, Mullings A, Wynter H H
Department of Obstetrics and Gynaecology, U.W.I., Jamaica.
West Indian Med J. 1993 Jun;42(2):62-4.
The technique of large loop excision of the transformation zone (LLETZ) as an alternative to destructive/ablative methods of treatment of cervical intraepithelial neoplasia (CIN) such as cryotherapy, laser vaporization and cone biopsy of uterine cervix is assessed. Forty-five patients underwent this procedure for either diagnostic or therapeutic reasons. It was well-tolerated, and minor bleeding occurred in 4.4% of patients. The quality of the histological specimen was excellent in all cases, only two showing evidence of charring artefacts. In 11 patients (24.4%), a more serious lesion was detected than that found at punch biopsy of the cervix. This method offers a cheaper and more effective alternative to laser vaporization and combines the benefits of the gold standard cone biopsy of the cervix with that of local ablative techniques.
评估了采用转化区大环形切除术（LLETZ）替代宫颈上皮内瘤变（CIN）的破坏性/消融性治疗方法（如冷冻疗法、激光汽化和宫颈锥形活检）的技术。45例患者因诊断或治疗原因接受了该手术。该手术耐受性良好，4.4%的患者出现轻微出血。所有病例的组织学标本质量都非常好，只有两例有炭化假象的迹象。11例患者（24.4%）检测到比宫颈活检时发现的更严重的病变。该方法为激光汽化提供了一种更便宜且更有效的替代方法，并将宫颈金标准锥形活检的优点与局部消融技术的优点结合起来。
