Morrison J A, Larsen R, Glatfelter L, Boggs D, Burton K, Smith C, Kelly K, Mellies M J, Khoury P, Glueck C J
Pediatrics. 1980 Apr;65(4):727-34.
Relationships between nutrient intakes and plasma lipids and lipoproteins were studied in 1,669 schoolchildren, aged 6 to 19 years; 948 were selected by random recall and 721 because of elevated plasma cholesterol or triglyceride (hyperlipidemic recall). Nutrient intake data was collected by using a 24-hour dietary recall. Median dietary cholesterol intakes for 6 to 9-year-old boys and girls in the random recall group were 222 and 230 mg/day, with polyunsaturated/saturated fat ratios of 0.34 and 0.33. For boys and girls, aged 10 to 12 years, median dietary cholesterol intakes were 296 and 235 mg/day, for 13 to 15 year olds, 343 and 237, and for 16 to 19 year olds, 418 and 221 mg/day. The dietary polyunsaturated/saturated fat ratios did not change appreciably with age. Partial correlation coefficients describing relationships between lipids, lipoproteins, and nutrients after adjustment for age, sex, race, and Quetelet index (W/H2) were calculated for all children (random and hyperlipidemic recall) after excluding children having plasma cholesterol, triglycerides, and calories less than or equal to the first or greater than or equal to the 99th percentiles for the random recall children. Plasma cholesterol was inversely and triglyceride positively correlated with dietary sucrose. Plasma low density lipoprotein cholesterol was inversely and triglyceride positively correlated with the dietary polyunsaturated/saturated fat ratio, total carbohydrate, and sugar. Potential relationships between nutrients and lipids-lipoproteins were also examined in children having low (first to tenth percentile), intermediate (45th to 55th percentile), and high (90th to 99th percentile) nutrient intake, after covariance adjustment for age, race, sex, and Quetelet index. Total plasma cholesterol fell as sucrose intake increased. Triglyceride rose along with caloric intake, total carbohydrate intake, and sucrose intake, while high density lipoprotein cholesterol levels fell with increasing caloric and sucrose intake. As dietary polyunsaturate ingestion rose from low to intermediate to high, plasma low density lipoprotein cholesterol increased. Nutrient intake may play a small but significant role relative to lipids and lipoproteins in children and, as such, may have importance relative to pediatric precursors of atherosclerosis.
对1669名6至19岁的学童进行了营养摄入与血浆脂质及脂蛋白之间关系的研究；其中948名通过随机回忆入选，721名因血浆胆固醇或甘油三酯升高（高脂血症回忆）入选。通过24小时饮食回忆收集营养摄入数据。随机回忆组中6至9岁男孩和女孩的膳食胆固醇摄入量中位数分别为222毫克/天和230毫克/天，多不饱和/饱和脂肪比率分别为0.34和0.33。10至12岁男孩和女孩的膳食胆固醇摄入量中位数分别为296毫克/天和235毫克/天，13至15岁的分别为343毫克/天和237毫克/天，16至19岁的分别为418毫克/天和221毫克/天。膳食多不饱和/饱和脂肪比率随年龄变化不明显。在排除血浆胆固醇、甘油三酯和热量低于或等于随机回忆儿童的第1百分位数或高于或等于第99百分位数的儿童后，计算了所有儿童（随机和高脂血症回忆）在调整年龄、性别、种族和体重指数（W/H2）后脂质、脂蛋白与营养素之间关系的偏相关系数。血浆胆固醇与膳食蔗糖呈负相关，甘油三酯与膳食蔗糖呈正相关。血浆低密度脂蛋白胆固醇与膳食多不饱和/饱和脂肪比率、总碳水化合物和糖呈负相关，甘油三酯与它们呈正相关。在对年龄、种族、性别和体重指数进行协方差调整后，还研究了营养摄入低（第1至第10百分位数）、中等（第45至第
