Glueck C J, Waldman G, McClish D K, Morrison J A, Khoury P, Larsen R, Salz K, Rifkind B M, Mattson F H
Arteriosclerosis. 1982 Nov-Dec;2(6):523-36. doi: 10.1161/01.atv.2.6.523.
Using the geographically and socioeconomically varied collaborative Lipid Research Clinics Prevalence Study data, this report focuses upon relationships between dietary intake and plasma lipids and lipoproteins in 1234 white children, 661 boys and 573 girls, aged 6-19 years who were sampled in a random recall (Visit 2) from large populations in six Lipid Research Clinics. Using multiple regression analysis, we found that in 6- to 12-year-old boys the dietary polyunsaturated-to-saturated fat ratio was inversely associated with plasma total and low density lipoprotein cholesterol and dietary cholesterol was positively associated with plasma high density lipoprotein cholesterol. In 13- to 19-year-old boys, high density lipoprotein cholesterol and the ratio of high density lipoprotein cholesterol to total cholesterol were inversely related to sucrose intake. In 6- to 12-year-old girls, plasma triglycerides were positively related to dietary sucrose. Using analysis of covariance in children having the lowest, middle, and top decile nutrient intakes, we found that higher carbohydrate intakes were associated with lower plasma total cholesterol in boys. The highest polyunsaturated fat intake (in 6- to 12-year-old girls) was associated with the lowest plasma cholesterol and very low density lipoprotein cholesterol. The highest cholesterol intake (in 6- to 12-year-old boys) was associated with the highest high density lipoprotein cholesterol levels. In girls, the highest sucrose intakes were associated with the highest plasma triglyceride levels. We conclude that the weak, but statistically significant, associations that we observed were meaningful relative to etiologies of nutrient-lipoprotein interrelationships, and should be useful in forming new hypotheses for focused metabolic ward studies.
本报告利用地域和社会经济情况各异的脂质研究诊所患病率协作研究数据，重点关注了1234名6至19岁白人儿童（661名男孩和573名女孩）的饮食摄入与血浆脂质及脂蛋白之间的关系。这些儿童是从六个脂质研究诊所的大量人群中随机抽取进行回忆调查（第二次访视）的。通过多元回归分析，我们发现，在6至12岁的男孩中，饮食中多不饱和脂肪与饱和脂肪的比例与血浆总胆固醇和低密度脂蛋白胆固醇呈负相关，而饮食胆固醇与血浆高密度脂蛋白胆固醇呈正相关。在13至19岁的男孩中，高密度脂蛋白胆固醇以及高密度脂蛋白胆固醇与总胆固醇的比例与蔗糖摄入量呈负相关。在6至12岁的女孩中，血浆甘油三酯与饮食中的蔗糖呈正相关。通过对营养素摄入量处于最低、中间和最高十分位数的儿童进行协方差分析，我们发现较高的碳水化合物摄入量与男孩较低的血浆总胆固醇相关。最高的多不饱和脂肪摄入量（6至12岁女孩）与最低的血浆胆固醇和极低密度脂蛋白胆固醇相关。最高的胆固醇摄入量（6至12岁男孩）与最高的高密度脂蛋白胆固醇水平相关。在女孩中，最高的蔗糖摄入量与最高的血浆甘油三酯水平相关。我们得出结论，我们观察到的这些微弱但具有统计学意义的关联相对于营养素与脂蛋白相互关系的病因具有重要意义，并且应该有助于形成针对重点代谢病房研究的新假设。
