Hiçsönmez G, Prozorova-Zamani V
Scand J Haematol. 1980 Jan;24(1):67-70. doi: 10.1111/j.1600-0609.1980.tb01320.x.
In 19 jaundiced newborns who had no evidence of kernicterus the effect of bilirubin on adenosine-5'-diphosphate (ADP), epinephrine and collagen-induced platelet aggregation was studied. Compared to 20 normal adult controls, no significant difference was found for ADP and collagen-induced platelet aggregation in jaundiced infants. However, with epinephrine, significantly decreased aggregation was observed, but this was also the case for non-jaundiced infants. This suggests that the reduced response to epinephrine in hyperbilirubinaemic infants is related to age rather than to bilirubin. Increased bilirubin is therefore not responsible for any increased bleeding tendency due to impaired platelet function.
在19例无核黄疸证据的黄疸新生儿中，研究了胆红素对腺苷-5'-二磷酸（ADP）、肾上腺素和胶原诱导的血小板聚集的影响。与20名正常成人对照组相比，黄疸婴儿中ADP和胶原诱导的血小板聚集未发现显著差异。然而，对于肾上腺素，观察到聚集显著降低，但非黄疸婴儿也是如此。这表明高胆红素血症婴儿对肾上腺素反应降低与年龄有关而非与胆红素有关。因此，胆红素升高并非因血小板功能受损导致出血倾向增加的原因。
