接受黑色素瘤移植的小鼠的存活率因对苯二酚而提高。
Survival of mice receiving melanoma transplants is promoted by hydroquinone.
作者信息
Chavin W, Jelonek E J, Reed A H, Binder L R
出版信息
Science. 1980 Apr 25;208(4442):408-10. doi: 10.1126/science.7367868.
PMID:7367868
Abstract
In BALB/c female mice with melanoma transplants, the incidence of "takes" is decreased and survival is increased by hydroquinone, a melanocytolytic agent. The mechanism of drug action is suggested by via DNA. The significant and high degree of positive response to hydroquinone treatment in vivo is encouraging for the clinical management of melanoma with melanocytolytic agents.
摘要
在移植了黑色素瘤的雌性BALB/c小鼠中，黑素细胞溶解剂对苯二酚可降低“移植成功”的发生率并提高生存率。药物作用机制表明是通过DNA起作用。对苯二酚体内治疗的显著且高度阳性反应，对于用黑素细胞溶解剂临床治疗黑色素瘤是令人鼓舞的。
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