Pifer J W, Hearne F T, Swanson F A, O'Donoghue J L
Epidemiology Section, Eastman Kodak Company, Rochester, NY 14652-6253, USA.
Int Arch Occup Environ Health. 1995;67(4):267-80. doi: 10.1007/BF00409409.
Mortality in a 1942-1990 cohort of 858 men and 21 women employed in the manufacture and use of hydroquinone was evaluated through 1991. Average exposure concentrations, 1949-1990, ranged from 0.1 to 6.0 mg/m3 for hydroquinone dust and from less than 0.1 to 0.3 for quinone vapor (estimated 8-h time-weighted averages). Compared with general population and occupational referents, there were statistically significant deficits in total mortality and deaths due to cancer. No significant excesses were observed for such hypothesized causes as kidney cancer [2 observed vs 1.3 expected (both control groups), P approximately 0.39], liver cancer (0 vs 0.8, 1.3), and leukemia (0 vs 2.3, 2.7). Dose-response analyses of selected causes of death, including renal carcinoma, demonstrated no statistically significant heterogeneities or linear trends according to estimated career hydroquinone exposure (mg/m3-years) or time from first exposure.
对1942年至1990年间受雇于对苯二酚制造和使用行业的858名男性和21名女性组成的队列的死亡率进行了评估，评估截止到1991年。1949年至1990年期间，对苯二酚粉尘的平均暴露浓度为0.1至6.0毫克/立方米，醌蒸气的平均暴露浓度为低于0.1至0.3（估计的8小时时间加权平均值）。与一般人群和职业对照相比，总死亡率和癌症死亡人数在统计学上有显著不足。对于肾癌（观察到2例，预期1.3例（两个对照组），P约为0.39）、肝癌（0例对0.8例、1.3例）和白血病（0例对2.3例、2.7例）等假设病因，未观察到显著超额情况。对选定死因（包括肾癌）的剂量反应分析表明，根据估计的职业对苯二酚暴露量（毫克/立方米-年）或首次暴露后的时间，未发现统计学上显著的异质性或线性趋势。
