Thomas R J
Surgery. 1980 May;87(5):539-44.
Hepatic glycogen levels were measured in rats both on oral food ad libitum and where intravenous nutrition was supplied at 0.1, 0.2, and 0.35 Kcal/gm of body weigh/day at 24 and 72 hours after injury. While on oral food rats with a closed femoral fracture had a lower level (25 +/- 6.5 mg/gm of liver) than normal (66 +/- 9.1 mg/gm of liver, P less than 0.005), 24 hours after injury. There was a corresponding rise in blood sugar (161 +/- 20 leads to 240 +/- 23 mg/100 ml, P less than 0.005) at 24 hours. However the food intake fell (23.8 +/- 1.5 leads to 16.6 +/- 2.4 gm/day, P less than 0.01) during the first 24 hours after the injury. When intravenous nutrition was given at a caloric level of 0.35 Kcal/gm/day, hepatic glycogen levels were above normal and there was no difference between injured and noninjured animals. At 0.2 Kcal/gm/day there was also no difference between injured and noninjured animals, but glycogen levels fell from norman levels (78 +/- 12.9 mg/gm) to lower levels (33 +/- 11.9 mg/gm, P less than 0.01) over the 24-hour to 72-hour period. Low levels of caloric intake (0.1 Kcal/gm/day) resulted in a fall in glycogen level in both injured and noninjured animals, with the decrease being significantly greater in the injured animals. It is concluded that maintenance of the caloric intake of rats at normal or high levels via the intravenous route can prevent the depletion of hepatic glycogen produced by a femoral fracture.
在受伤后24小时和72小时，对自由采食的大鼠以及按体重每天每克给予0.1、0.2和0.35千卡静脉营养的大鼠测量肝糖原水平。受伤后24小时，自由采食的闭合性股骨骨折大鼠的肝糖原水平（25±6.5毫克/克肝脏）低于正常水平（66±9.1毫克/克肝脏，P<0.005）。24小时时血糖相应升高（161±20升至240±23毫克/100毫升，P<0.005）。然而，受伤后的头24小时内食物摄入量下降（23.8±1.5降至16.6±2.4克/天，P<0.01）。当按每天每克0.35千卡的热量水平给予静脉营养时，肝糖原水平高于正常，受伤和未受伤动物之间无差异。按每天每克0.2千卡给予时，受伤和未受伤动物之间也无差异，但在24小时至72小时期间，糖原水平从正常水平（78±12.9毫克/克）降至较低水平（33±11.9毫克/克，P<0.01）。低热量摄入水平（每天每克0.1千卡）导致受伤和未受伤动物的糖原水平均下降，受伤动物的下降幅度明显更大。结论是，通过静脉途径将大鼠的热量摄入维持在正常或高水平可以防止股骨骨折导致的肝糖原消耗。
