Chan S T, McLaughlin S J, Ponting G A, Biglin J, Dudley H A
Br Med J (Clin Res Ed). 1986 Oct 25;293(6554):1055-6. doi: 10.1136/bmj.293.6554.1055.
The force-frequency characteristics and maximal relaxation rate of the adductor pollicis muscle were measured before and after 48 hours of intravenous loading with glucose (104.5 kJ (25 kcal)/kg/24 h) and potassium (20 mmol(mEq)/500 ml glucose) in eight undernourished patients about to undergo surgery. Both variables of skeletal muscle performance, which were depressed when compared with data from 100 healthy volunteers, improved significantly after glucose-potassium loading. The improvement was accompanied by restoration of muscle glycogen values and return of respiratory exchange ratios towards unity. These results imply that if muscle power is a yardstick for preoperative nutritional rehabilitation then a simple regimen of energy-electrolyte repletion may be cost effective in preparing undernourished patients for major surgery.
在8名即将接受手术的营养不良患者中，于静脉输注葡萄糖（104.5千焦（25千卡）/千克/24小时）和钾（20毫摩尔（毫克当量）/500毫升葡萄糖）48小时前后，测量了拇收肌的力-频率特性和最大舒张速率。与100名健康志愿者的数据相比，这两个骨骼肌性能变量在输注前均降低，在葡萄糖-钾负荷后显著改善。这种改善伴随着肌肉糖原值的恢复以及呼吸交换率恢复至接近1。这些结果表明，如果肌肉力量是术前营养康复的一个衡量标准，那么简单的能量-电解质补充方案在为营养不良患者进行大手术做准备时可能具有成本效益。
