Watson A D
Am J Vet Res. 1980 Feb;41(2):293-4.
After a base-line period (14 days), five cats were orally given 50 mg of chloramphenicol every 12 hours for 21 days. Clinical signs of toxicosis were CNS depression, reduced intake of food and water, and weight loss. Changes in peripheral blood included lower platelet counts after treatment for 1 week and fewer neutrophils after treatment for 3 weeks; one cat developed lymphocytopenia after 1 week and neutropenia after 2 weeks. Changes in bone marrow at the end of treatment comprised vacuolation of early myeloid cells and lymphocytes, and reduced myeloid maturation ratio, and some cats also had reduced marrow cellularity, or increased myeloid:erythroid ratio, or both of these.
在基线期（14天）后，五只猫每12小时口服50毫克氯霉素，持续21天。中毒的临床症状包括中枢神经系统抑制、食物和水摄入量减少以及体重减轻。外周血变化包括治疗1周后血小板计数降低，治疗3周后中性粒细胞减少；一只猫在1周后出现淋巴细胞减少，2周后出现中性粒细胞减少。治疗结束时骨髓的变化包括早期髓样细胞和淋巴细胞空泡化、髓样成熟率降低，一些猫还出现骨髓细胞减少，或髓系：红系比例增加，或两者皆有。
