Winston V D, Bolen J B, Consigli R A
Am J Vet Res. 1980 Mar;41(3):391-4.
A study was done to examine the effects of butylated hydroxytoluene (BHT) on purified Newcastle disease virus (NDV). Treatment of the virus with 50 microgram of BHT/ml caused 92% inactivation of the virion infectivity. Virion adsorption to chicken-embryonated cells was inhibited 32% and synthesis of intracellular hemagglutinin was inhibited 29%. Electron microscopy of the BHT-treated virions revealed virion envelope damage. Chicken-embryonated cells treated with 25 microgram of BHT/ml before NDV infection demonstrated 65% inhibition of NDV progeny production.
