皮肤色素沉着过度和黑素内脂质小滴。
Cutaneous hypermelanosis and intramelanotic lipid droplets.
作者信息
Ortonne J P, Perrot H, Schmitt D, Bioulac P
出版信息
Arch Dermatol. 1980 Mar;116(3):301-6.
Intramelanocytic lipid droplets have been observed in 12 patients with different types of hypermelanosis of the skin. These include drug-induced hypermelanosis, hypermelanosis secondary to use of physical agents, hypermelanotic morphea, generalized scleroderma with diffuse hypermelanosis, a hyperkeratotic tumor in xeroderma pigmentosum, aberrant mongolian spot, and methoxsalen-ultraviolet-A-induced hypermelanosis. Lipid storage was selectively observed in melanocytes. Most of the melanocytes with lipid vacuoles showed ultrastructural signs of hyperactive melanosome synthesis and certain cytoplasmic abnormalities such as melanosomal autophagic vacuole formation and mitochondrial alterations. The importance and the origin of the lipid droplets remain unclear.
在12例不同类型的皮肤色素沉着过度患者中观察到黑素细胞内脂质小滴。这些类型包括药物性色素沉着过度、物理因素所致色素沉着过度、色素沉着性硬斑病、伴有弥漫性色素沉着过度的系统性硬皮病、着色性干皮病中的角化过度性肿瘤、异常蒙古斑以及甲氧沙林-紫外线A诱导的色素沉着过度。脂质储存选择性地出现在黑素细胞中。大多数含有脂质空泡的黑素细胞显示出黑素小体合成活跃的超微结构特征以及某些细胞质异常，如黑素小体自噬空泡形成和线粒体改变。脂质小滴的重要性和来源仍不清楚。
Zotero 插件