Sears H F, Hopson R, Inouye W, Rizzo T, Grotzinger P J
Ann Surg. 1980 Apr;191(4):488-93. doi: 10.1097/00000658-198004000-00016.
Over ten years, 70 patients with soft tissue sarcoma were treated for their primary tumors at the hospital of The Fox Chase Cancer Center. The clinical characteristics of these tumors are correlated with the outcome of various management efforts. The results of these evaluations identify three groups that can provide the basis for future treatment decisions and stratification for randomized studies of management options. The first group of patients, those with small well differentiated tumors, have no systemic spread regardless of the treatment modality used. The second group, those with large (greater than 5 cm) tumors that are moderately or poorly differentiated, do uniformly poorly despite the management techniques used. An intermediate group, those with high grade or large size but not both, have outcomes which may be correlated to treatment modalities.
在过去十年间，70例软组织肉瘤患者在福克斯蔡斯癌症中心医院接受了原发性肿瘤治疗。这些肿瘤的临床特征与各种治疗措施的结果相关。这些评估结果确定了三组患者，可为未来的治疗决策以及管理方案随机研究的分层提供依据。第一组患者，即肿瘤小且分化良好的患者，无论采用何种治疗方式均无全身转移。第二组患者，即肿瘤大（大于5厘米）且分化中等或较差的患者，无论采用何种管理技术，预后均较差。中间组患者，即肿瘤分级高或体积大但并非两者兼具的患者，其预后可能与治疗方式相关。
