Chin G N, Chi E Y, Bunt A H
Arch Ophthalmol. 1980 Apr;98(4):720-4. doi: 10.1001/archopht.1980.01020030714014.
Ultrastructural and histochemical studies were performed on conjunctival concretions (yellow spots in the tarsal conjunctiva) from two patients who had associated atopic keratoconjunctivitis and posttrachomatous degeneration. By electron microscopy, these concretions were composed of finely granular material and membranous debris accumulating in the conjunctival subepithelium. Histochemically, concretions stained strongly positive for phospholipid and elastin, weakly positive for neutral polysaccharides and lipid, and were negative for amyloid, collagen, glycogen, iron, mucopolysaccharides, RNA, and DNA. In view of the absence of both calcium and phosphate in the accumulated material, the use of the term "lithiasis" is misleading and should be avoided. These findings support a hypothesis that concretions that follow chronic conjunctivitis represent products of cellular degeneration.
对两名患有特应性角结膜炎和沙眼后变性的患者的结膜结石（睑结膜黄斑）进行了超微结构和组织化学研究。通过电子显微镜观察，这些结石由细颗粒物质和膜碎片组成，积聚在结膜上皮下。组织化学上，结石对磷脂和弹性蛋白呈强阳性染色，对中性多糖和脂质呈弱阳性染色，对淀粉样蛋白、胶原蛋白、糖原、铁、粘多糖、RNA和DNA呈阴性染色。鉴于积聚物质中既没有钙也没有磷，使用“结石症”一词会产生误导，应避免使用。这些发现支持了一个假设，即慢性结膜炎后的结石是细胞变性的产物。
