Dutton J J, Krupin T, Waltman S R, Koloms B A, Becker B
Arch Ophthalmol. 1980 Apr;98(4):731-3. doi: 10.1001/archopht.1980.01020030725017.
Fluorophotometry was used to evaluate alterations in the blood-ocular barrier to fluorescein in rats with experimental hypertension. One hour after intravenous injection of fluorescein, 16.6 mg/kg, concentrations in the anterior chamber were increased from mean normotensive values of 135 micrograms/mL to 299 micrograms/mL (P = .005) in animals with severe hypertension. Fluorescein concentrations in the vitreous also were increased from 50 micrograms/mL in normotensive rats to 109 micrograms/mL (P = .005) in hypertensive animals. With increasing duration of systemic pressures above 160 mm Hg, anterior chamber fluorescein concentrations rose from base-line of 135 micrograms/mL to 210 micrograms/mL after one to four weeks of hypertension, and to 394 micrograms/mL after five to eight weeks (P = .005). Similarly, vitreous concentrations increased from baseline of 50 micrograms/mL to 76 micrgrams/mL and 136 micrograms/mL (P = .005) after the shorter and longer periods of hypertension. Control of hypertension with return of systolic pressure to below 120 mm Hg caused a reversal of the abnormal fluorescein permeability.
采用荧光光度法评估实验性高血压大鼠血-眼屏障对荧光素的改变。静脉注射16.6mg/kg荧光素1小时后，重度高血压动物前房中的浓度从正常血压动物的平均135μg/mL升至299μg/mL（P = 0.005）。玻璃体中的荧光素浓度也从正常血压大鼠的50μg/mL升至高血压动物的109μg/mL（P = 0.005）。随着全身血压高于160mmHg的持续时间增加，高血压1至4周后，前房荧光素浓度从基线的135μg/mL升至210μg/mL，5至8周后升至394μg/mL（P = 0.005）。同样，高血压持续时间较短和较长后，玻璃体浓度分别从基线的50μg/mL升至76μg/mL和136μg/mL（P = 0.005）。收缩压恢复至120mmHg以下对高血压的控制导致荧光素异常通透性的逆转。
