Lowther D A, Sandy J D, Santer V B, Brown H L
Arthritis Rheum. 1978 Jul-Aug;21(6):675-80. doi: 10.1002/art.1780210611.
An arthritis was induced in rabbits immunized with human serum albumin by injection of antigen into the hind knee joint. Histological changes in the synovial membrane and an increase in polymorphonuclear granulocytes in the synovial fluid indicated an inflammatory response similar to that described with fibrin as antigen (1). The arthritis was accompanied by no significant change in the collagen content, but a marked decrease in the proteoglycan content of the cartilage was noted. Cartilage from inflamed joints generally exhibited a decreased ability to synthesize proteoglycan in vitro.
通过将抗原注射到兔后膝关节中，用人血清白蛋白免疫兔诱发关节炎。滑膜的组织学变化以及滑液中多形核粒细胞的增加表明存在类似于以纤维蛋白作为抗原所描述的炎症反应(1)。关节炎伴有胶原蛋白含量无显著变化，但注意到软骨中蛋白聚糖含量显著降低。来自发炎关节的软骨在体外通常表现出合成蛋白聚糖的能力下降。
