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1
Inhibition of urea-cycle activity by high concentrations of alanine.高浓度丙氨酸对尿素循环活性的抑制作用。
Biochem J. 1980 Jan 15;186(1):1-4. doi: 10.1042/bj1860001.
2
Real-time study of the urea cycle using 15N n.m.r. in the isolated perfused rat liver.利用15N核磁共振对离体灌注大鼠肝脏中的尿素循环进行实时研究。
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3
Effect of ornithine and lactate on urea synthesis in isolated hepatocytes.鸟氨酸和乳酸对分离肝细胞中尿素合成的影响。
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4
Inhibition of ureagenesis by valproate in rat hepatocytes. Role of N-acetylglutamate and acetyl-CoA.丙戊酸盐对大鼠肝细胞尿素生成的抑制作用。N-乙酰谷氨酸和乙酰辅酶A的作用。
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5
Sources of ammonia for mammalian urea synthesis.哺乳动物尿素合成中氨的来源。
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6
Channeling of urea cycle intermediates in situ in permeabilized hepatocytes.尿素循环中间产物在通透化肝细胞内的原位转运
J Biol Chem. 1989 Mar 5;264(7):4038-44.
7
Effect of dietary protein level on urea synthesis in isolated rat hepatocytes.日粮蛋白质水平对离体大鼠肝细胞尿素合成的影响。
J Nutr. 1977 Apr;107(4):561-6. doi: 10.1093/jn/107.4.561.
8
Regulation of urea synthesis in rat liver. Inhibition of urea synthesis by L-norvaline.大鼠肝脏中尿素合成的调节。L-正缬氨酸对尿素合成的抑制作用。
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9
NADP-specific isocitrate dehydrogenase in regulation of urea synthesis in rat hepatocytes.烟酰胺腺嘌呤二核苷酸磷酸特异性异柠檬酸脱氢酶对大鼠肝细胞尿素合成的调节作用
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10
Control by pH of urea synthesis in isolated rat hepatocytes.分离的大鼠肝细胞中尿素合成的pH调控
Eur J Biochem. 1988 Mar 1;172(2):465-9. doi: 10.1111/j.1432-1033.1988.tb13911.x.

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Genetically predicted plasma levels of amino acids and metabolic dysfunction-associated fatty liver disease risk: a Mendelian randomization study.基于遗传预测的氨基酸血浆水平与代谢相关脂肪性肝病风险：一项孟德尔随机化研究。
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Shifts in the carbohydrate, polyol, and amino acid pools during rapid cold-hardening and diapause-associated cold-hardening in flesh flies (Sarcophaga crassipalpis): a metabolomic comparison.麻蝇（Sarcophaga crassipalpis）快速冷驯化和滞育相关冷驯化过程中碳水化合物、多元醇和氨基酸库的变化：代谢组学比较
J Comp Physiol B. 2007 Oct;177(7):753-63. doi: 10.1007/s00360-007-0172-5. Epub 2007 Jun 19.
3
Mitochondrial and cytosolic ATP/ADP ratios in isolated hepatocytes. A comparison of the digitonin method and the non-aqueous fractionation procedure.分离的肝细胞中线粒体和胞质的ATP/ADP比率：洋地黄皂苷法与非水分离法的比较
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4
Control of alanine metabolism in rat liver by transport processes or cellular metabolism.通过转运过程或细胞代谢对大鼠肝脏中丙氨酸代谢的调控。
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Exogenous hyperglucagonaemia in insulin controlled diabetic rats increases urea excretion and nitrogen loss from organs.胰岛素控制的糖尿病大鼠外源性高胰高血糖素血症会增加尿素排泄以及器官的氮损失。
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本文引用的文献

1
The enzymic hydrolysis of adenosine triphosphate by liver mitochondria. I. Activities at different pH values.肝脏线粒体对三磷酸腺苷的酶促水解作用。I. 不同pH值下的活性
Biochem J. 1957 Dec;67(4):558-72. doi: 10.1042/bj0670558.
2
Purification and properties of arginase of rat kidney.大鼠肾脏精氨酸酶的纯化及性质
Biochem J. 1973 Aug;133(4):779-88. doi: 10.1042/bj1330779.
3
Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics.来自粪链球菌和牛肝的鸟氨酸转氨甲酰酶。II. 氨甲酰磷酸和L-正缬氨酸的多个结合位点，与稳态动力学的相关性。
J Biol Chem. 1972 Mar 25;247(6):1654-68.
4
The distribution of hepatic metabolites and the control of the pathways of carbohydrate metabolism in animals of different dietary and hormonal status.不同饮食和激素状态动物肝脏代谢物的分布及碳水化合物代谢途径的调控。
Arch Biochem Biophys. 1971 Apr;143(2):617-63. doi: 10.1016/0003-9861(71)90247-5.
5
Some regulatory mechanisms in the synthesis of urea in the mammalian liver.哺乳动物肝脏中尿素合成的一些调节机制。
Adv Enzyme Regul. 1973;11:361-77. doi: 10.1016/0065-2571(73)90024-1.
6
Effects of ischaemia on metabolite concentrations in rat liver.缺血对大鼠肝脏代谢物浓度的影响。
Biochem J. 1970 Mar;117(1):91-6. doi: 10.1042/bj1170091.
7
Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride.氯化铵给药后大鼠肝脏内丙氨酸和天冬氨酸形成的机制。
Biochem J. 1974 Mar;138(3):453-62. doi: 10.1042/bj1380453.
8
Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes.阴离子跨线粒体膜转运在分离的大鼠肝细胞氨合成尿素调控中的作用。
J Biol Chem. 1975 Oct 10;250(19):7728-38.
9
Amino acid metabolism in man.人类的氨基酸代谢
Annu Rev Biochem. 1975;44:933-55. doi: 10.1146/annurev.bi.44.070175.004441.
10
Prolone metabolism in isolated rat liver cells.原洛酮在离体大鼠肝细胞中的代谢。
Biochem J. 1978 Mar 15;170(3):699-707. doi: 10.1042/bj1700699.

高浓度丙氨酸对尿素循环活性的抑制作用。

Inhibition of urea-cycle activity by high concentrations of alanine.

作者信息

Hensgens H E, Meijer A J

出版信息

Biochem J. 1980 Jan 15;186(1):1-4. doi: 10.1042/bj1860001.

DOI:10.1042/bj1860001
PMID:7370000
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161497/
Abstract
  1. Conditions are described in which high intracellular alanine concentrations inhibit urea-cycle flux in isolated hepatocytes. 2. Inhibition of urea-cycle flux by added alanine is DL-cycloserine-insensitive and is accompanied by an increase in intracellular citrulline and a decrease in ornithine. 3. Argininosuccinate synthetase (EC 6.3.4.5) activity in rat liver cytosol is inhibited by alanine in a competitive manner with respect to citrulline. It is concluded that this effects is the primary cause of inhibition of urea-cycle flux by alanine.
摘要
  1. 本文描述了在分离的肝细胞中，高细胞内丙氨酸浓度抑制尿素循环通量的条件。2. 添加丙氨酸对尿素循环通量的抑制作用对DL-环丝氨酸不敏感，且伴随着细胞内瓜氨酸增加和鸟氨酸减少。3. 大鼠肝细胞溶胶中的精氨琥珀酸合成酶（EC 6.3.4.5）活性被丙氨酸以相对于瓜氨酸的竞争性方式抑制。得出的结论是，这种效应是丙氨酸抑制尿素循环通量的主要原因。