Ronneberger H, Schwinn H
Arzneimittelforschung. 1980;30(1):30-3.
The influence of phospholipids and their combination with prothrombin and calcium on coagulation both normal and affected by acetylsalicylic acid (ASA) was investigated by determination of the bleeding time of mice, thrombelastographic (TEG) measurements and counting of thrombocytes of rabbits. Bleeding times and times of the TEG were prolonged after oral application of ASA, while thrombus stability was not altered. The number of thrombocytes decreased. Bleeding- and TEG-times normalized after injection of phospholipids. This effect was increased and of longer duration when phospholipids were combined with calcium and prothrombin. Decrease of the number of thrombocytes caused by pretreatment with ASA normalized only after injection of phospholipids together with prothrombin and calcium. The number of thrombocytes was not negatively influenced by the therapy in animals with normal coagulation.
通过测定小鼠出血时间、血栓弹力图（TEG）测量以及兔血小板计数，研究了磷脂及其与凝血酶原和钙的组合对正常凝血以及受乙酰水杨酸（ASA）影响的凝血的作用。口服ASA后，出血时间和TEG时间延长，而血栓稳定性未改变。血小板数量减少。注射磷脂后，出血时间和TEG时间恢复正常。当磷脂与钙和凝血酶原联合使用时，这种效果增强且持续时间更长。仅在注射磷脂与凝血酶原和钙后，由ASA预处理引起的血小板数量减少才恢复正常。在凝血正常的动物中，该治疗对血小板数量没有负面影响。
