Labie C
Arzneimittelforschung. 1980;30(1a):173-81.
The investigation on the possible teratogenic activity of a vaccinal formula of ribosomes of Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes A12 and Haemophilus influenzae (D 53) was carried out in three animal species: rats, mice, rabbits. The trials were performed on two generatins of rats and mice, and on one single generation of rabbits. D 53 was given in s.c. injections (6 days a week) for 8 days before mating the females, and then until the females dropped (or were sacrificed when foetuses had to be removed by Caesarean operation). The possible teratogenic or embryotoxic effects of D 53 were evaluated using the following checks: fertility rates in the mated females; rates of placenta-foetal resorptions; abnormalites in foetuses and offspring (dissection and skeletal staining). In the above experimental conditions, D 53 had no embryotoxic and teratogenic activity in the 3 animal species used.
对肺炎克雷伯菌、肺炎链球菌、化脓性链球菌A12和流感嗜血杆菌（D 53）核糖体疫苗配方的潜在致畸活性进行了研究，实验动物为三种动物：大鼠、小鼠、兔子。对两代大鼠和小鼠以及一代兔子进行了试验。在雌性动物交配前8天，每周皮下注射6天D 53，持续8天，然后持续给药直至雌性动物分娩（或在必须通过剖腹产取出胎儿时将其处死）。通过以下检查评估D 53可能的致畸或胚胎毒性作用：交配雌性动物的生育率；胎盘 - 胎儿吸收发生率；胎儿和后代的异常情况（解剖和骨骼染色）。在上述实验条件下，D 53在所用的3种动物中没有胚胎毒性和致畸活性。
