Takigawa M, Mogenson G J
No To Shinkei. 1980 Mar;32(3):299-304.
In recent years, the nucleus accumbens (NAS) has gained prominence because of an interest in the role of catecholamine in the intracranial self-stimulation (ICSS). The NAS receives strong projections from dopamine of the ventral tegmemtal area (VTA) which form the meso-limbic dopamine pathway (A10). The major purpose of the present study was to investigate the ICSS of NAS with special emphasis on its associated behavior. The results obtained were as follows: 1. ICSS was observed in rats with electrodes in the NAS. The rate of its ICSS was 230 +/- 142/15 min. 2. Antidromic spikes (AS) in the VTA were observed with stimulation of NAS including stimulation of sites associated with ICSS. The latency of AS was 25.5 +/- 4.3 msec. (range 10.0-42.0 msec). 3. ICSS of NAS was chiefly associated with "approach-escape" behavior and/or sniffing for which its electrodes were observed to distribute on widespread scatter through NAS. The electrodes of digging and/or licking groups were localized historogically in the vicinity of the commissura anterior.
近年来，由于对儿茶酚胺在颅内自我刺激（ICSS）中的作用感兴趣，伏隔核（NAS）受到了广泛关注。NAS接受来自腹侧被盖区（VTA）多巴胺的强烈投射，这些投射形成了中脑边缘多巴胺通路（A10）。本研究的主要目的是研究NAS的ICSS，并特别强调其相关行为。获得的结果如下：1. 在电极植入NAS的大鼠中观察到ICSS。其ICSS频率为230±142/15分钟。2. 刺激NAS（包括刺激与ICSS相关的部位）时，在VTA中观察到逆向动作电位（AS）。AS的潜伏期为25.5±4.3毫秒（范围为10.0 - 42.0毫秒）。3. NAS的ICSS主要与“趋近 - 逃避”行为和/或嗅探有关，观察到其电极在NAS中广泛分散分布。挖掘和/或舔舐组的电极在组织学上位于前连合附近。
