Takigawa M, Matsumoto K
No To Shinkei. 1980 Jun;32(6):565-9.
The supracallosal bundle (SCB) and prefrontal cortex (PFC) receive projection from medial forbrain bundle (MFB) of the lateral hypothalamus (LH) in relation to reward system. The major purpose of the present study was to compare the intracranial self-stimulation (ICSS) rate of both the SCB and PFC with special emphasis on its associated behavior. The results obtained were as follows: 1) self-stimulation was obtained with electrodes historogically varified as being in the SCB (16 of 23 electrodes positive for ICSS) and the medial PFC (3 of 16 electrodes positive for ICSS). Electrodes dorsal and far lateral to the SCB and PFC were mainly negative (see Fig. 1). 2) Rats with SCB or PFC electrodes, chiefly showed a rearing associated with its ICSS. When stimulation electrodes were more posterior or lateral sites in the SCB and PFC, clonic movements of forelimb and head were occasionally observed (Fig. 1). 3) For neuron in the LH, stimulation of the SCB via chronic electrodes positive for ICSS produced two characteristic types, i.e. postinhibitory rebound type (Fig. 2A) and driven inhibitory type (Fig. 2B-1). It was suggested that fibers of MFB were activated by stimulating SCB-ICSS sites.
胼胝体上束（SCB）和前额叶皮质（PFC）接收来自外侧下丘脑（LH）内侧前脑束（MFB）与奖赏系统相关的投射。本研究的主要目的是比较SCB和PFC的颅内自我刺激（ICSS）率，并特别强调其相关行为。获得的结果如下：1）在经组织学验证位于SCB（23个电极中有16个ICSS呈阳性）和内侧PFC（16个电极中有3个ICSS呈阳性）的电极处获得了自我刺激。位于SCB和PFC背侧及外侧远处的电极主要呈阴性（见图1）。2）植入SCB或PFC电极的大鼠，主要表现出与ICSS相关的竖立体位。当刺激电极位于SCB和PFC更靠后的位置或外侧部位时，偶尔会观察到前肢和头部的阵挛性运动（图1）。3）对于LH中的神经元，通过ICSS呈阳性的慢性电极刺激SCB产生了两种特征类型，即抑制后反弹型（图2A）和驱动抑制型（图2B - 1）。提示刺激SCB - ICSS部位可激活MFB的纤维。
