O'Neill G J, Stebbing N
Br J Cancer. 1980 Feb;41(2):243-9. doi: 10.1038/bjc.1980.36.
Administration of C. parvum alone did not improve the survival of C57BL/6 mice injected with the EL4 lymphoma. The anti-tumour effect of anti-EL4 Ig was however increased by C. parvum treatment, and the combination therapy of anti-EL4 Ig and cytotoxic drugs was even more improved. However, C. parvum only had this effect when given by the same i.p. route as the tumour cells, and the effect was greater when C. parvum was injected 5 days before than 1 day after tumour cells.
单独给予微小隐孢子虫并不能提高注射了EL4淋巴瘤的C57BL/6小鼠的存活率。然而，微小隐孢子虫治疗增强了抗EL4 Ig的抗肿瘤作用，抗EL4 Ig与细胞毒性药物的联合治疗效果更佳。不过，微小隐孢子虫只有通过与肿瘤细胞相同的腹腔注射途径给药才有此效果，且在肿瘤细胞注射前5天注射微小隐孢子虫比在肿瘤细胞注射后1天注射效果更好。
