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亚急性硬化性全脑炎(SSPE)脑脊液(CSF)中一种新的脑特异性蛋白。

A new brain specific protein in the cerebrospinal fluid (CSF) of subacute sclerosing panencephalitis (SSPE).

作者信息

Doutriaux C, Alle-Ando L, Attias J, Clerc M

出版信息

Biomedicine. 1980 Feb;33(1):24-6.

PMID:7370384
Abstract

A rabbit immune serum against SSPE CSF reveals in these CSF, in addition to IgG, another protein with electrophoretic gamma-mobility which is never revealed by anti-normal human serum nor by anti-normal CSF. This protein, called B.T., has been found in 5 out of 8 CSF studied. The same immune serum against SSPE CSF reveals in normal brain extracts a specific protein sharing antigenic identity with the fraction B.T. from SSPE CSF. This brain protein is located in the white matter. It has not been found in the grey matter, nor in other tissue extracts. Due to its solubility and electrophoretic properties, this brain protein B.T. is not comparable with any of the brain specific proteins known at this time.

摘要

一种针对亚急性硬化性全脑炎(SSPE)脑脊液的兔免疫血清显示,在这些脑脊液中,除了IgG之外,还有另一种具有电泳γ迁移率的蛋白质,而抗正常人血清和抗正常脑脊液均未显示出这种蛋白质。这种名为B.T.的蛋白质在8份研究的脑脊液中有5份中被发现。同样针对SSPE脑脊液的免疫血清在正常脑提取物中显示出一种与SSPE脑脊液中的B.T.组分具有抗原同一性的特异性蛋白质。这种脑蛋白位于白质中。在灰质和其他组织提取物中均未发现。由于其溶解性和电泳特性,这种脑蛋白B.T.与目前已知的任何脑特异性蛋白质都不可比。

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