多发性硬化症和亚急性硬化性全脑炎中脑内IgG的合成
IgG synthesis within the brain in multiple sclerosis and subacute sclerosing panencephalitis.
作者信息
Ewan P W, Lachmann P J
出版信息
Clin Exp Immunol. 1979 Feb;35(2):227-35.
Abstract
Intracerebral IgG synthesis was measured in patients with multiple sclerosis (MS), subacute sclerosing panencephalitis (SSPE) and in two control groups--patients with other neurological disorders and patients with non-neurological diseases. Significantly increased synthesis was found at all times in SSPE (P less than 0.001). Significantly elevated values were also found in MS (P less than 0.001), but in this group increased values were found mainly during relapse. These findings emphasize the immunological component in SSPE where there is known to be persistent measles virus infection in the brain, and in MS where the aetiology is unknown. Intracerebral IgG synthesis appears to be of diagnostic value in MS. The cerebrospinal fluid (CSF) IgG/total protein ratio was also measured in MS, and correlated only moderately well with the calculated IgG synthesis, indicating that the ratio provides a cruder estimate of intracerebral IgG synthesis.
摘要
对患有多发性硬化症（MS）、亚急性硬化性全脑炎（SSPE）的患者以及两个对照组——患有其他神经系统疾病的患者和患有非神经系统疾病的患者，进行了脑内IgG合成的测量。在SSPE患者中，所有时间点均发现合成显著增加（P<0.001）。在MS患者中也发现了显著升高的值（P<0.001），但在该组中，升高的值主要出现在复发期间。这些发现强调了SSPE中的免疫成分，已知该疾病存在大脑中持续的麻疹病毒感染，以及病因不明的MS中的免疫成分。脑内IgG合成似乎对MS具有诊断价值。还对MS患者的脑脊液（CSF）IgG/总蛋白比值进行了测量，其与计算出的IgG合成仅中度相关，表明该比值对脑内IgG合成的估计较为粗略。
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