[Change in the activity of the histamine and serotonin systems in acute obstruction of the mesenteric vessels].

It was shown in experiments on 24 dogs that acute occlusion of the cranial mesenteric artery results, depending on its duration, in biphasic changes in the activity of the histamine and serotonin systems. During intestinal ischemia there was an enhanced discharge of histamine and serotonin from mast cells with activation of their inhibitors (di- and monoamine oxidase). A remarkable inhibition of the histamine system enzymatic unit apart from a fall in serotonin activity because of progressing body poisoning by substances of microbial and metabolic origin were observed during intestinal infarction.