[Experimental occlusion of the superior mesenteric artery: further evidence of the influence of histamine and diamine oxidase in the development of shock (author's transl)].

In shock produced by temporary superior mesenteric artery occlusion the plasma histamine concentration was enhanced following release of the mesenteric blockade. Furthermore, an inhibition of the diamine oxidase catalysed histamine inactivation resulted in an aggravation of the shock development. These processes, already shown in dogs and mini pigs, were also observed in rabbits. Histamine receptor antagonists abolished the effect of the enhanced histamine concentration appearing in the circulation following inhibition of diamine oxidase. In human intestinal tract a fairly similar distribution of histamine and diamine oxidase was found as in the mammals studied. Thus the indicated pathobiochemical processes should be reckoned with in patients suffering from circulatory disorders of the intestinal tract.