Perret C, Cabelguen J M
Brain Res. 1980 Apr 14;187(2):333-52. doi: 10.1016/0006-8993(80)90207-3.
In acute decorticate (thalamic) cats, efferent activities to various hindlimb muscles during the locomotor cycle were studied, using several complementary methods: muscle and motor nerve recordings, monosynaptic testing, intracellular recording from motoneurones, recording of fusimotor actions on single Ia afferents. The limb was fixed and peripheral influences could be either increased by exteroceptive stimulations or decreased by curarization and/or deafferentation. Our main results were the following: in all studied muscles, there is an alpha-gamma coactivation; there are pure flexor and pure extensor muscles with simple alternating activities; bifunctional pluriarticular muscles show complex activations which allow the division of the locomotor cycle into a flexion, an extension and two transition phases; alpha motoneurones of these muscles receive both flexor and extensor commands; the relative importance of the corresponding excitations depends on interactions between these central commands and peripheral inflow, especially through afferents acting according to the flexor reflex pattern. Based on these results, an attempt is made to explain how the complex and variable efferent activity can arise from an initially simple rhythmic command and produce the biomechanically adapted locomotor movement of the hindlimb.
在急性去皮质（丘脑）猫中，利用多种互补方法研究了运动周期中对各种后肢肌肉的传出活动：肌肉和运动神经记录、单突触测试、运动神经元的细胞内记录、对单个Ia传入纤维的肌梭运动作用记录。肢体被固定，通过外感受性刺激可增强外周影响，通过箭毒处理和/或传入神经切断可减弱外周影响。我们的主要结果如下：在所有研究的肌肉中，存在α-γ共同激活；有具有简单交替活动的纯屈肌和纯伸肌；双功能多关节肌肉表现出复杂的激活，这使得运动周期可分为屈曲、伸展和两个过渡阶段；这些肌肉的α运动神经元接受屈肌和伸肌指令；相应兴奋的相对重要性取决于这些中枢指令与外周传入之间的相互作用，尤其是通过按照屈肌反射模式起作用的传入神经。基于这些结果，试图解释复杂多变的传出活动如何从最初简单的节律性指令产生，并产生后肢生物力学适应性的运动。
