脑对胃液分泌的调节：神经肽的影响
Brain regulation of gastric secretion: influence of neuropeptides.
作者信息
Taché Y, Vale W, Rivier J, Brown M
出版信息
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5515-9. doi: 10.1073/pnas.77.9.5515.
Several neuropeptides injected intracisternally were assessed for their effects on gastric secretion in rats. Bombesin (1 microgram) completely suppressed gastric acid secretion, produced the volume of gastric secretion, and partially blocked insulin- or 2-deoxy-D-glucose-induced stimulation of gastric acid output. The inhibitory effect of this peptide is dose-dependent, long-acting, reversible, and specific. Bombesin response appears to be central nervous system-mediated; its expression is not dependent on the vagus nerve or the adrenal glands, and does not rely on a decrease in gastrin secretion. Among seven other peptides tested, only beta-endorphin and a potent gonadotropin releasing-factor (gonadoliberin) agonist significantly reduced gastric acid secretion, with an activity ca. 100 times less than that of bombesin. The presence of bombesin-like material in rat brain and the high potency of bombesin to inhibit gastric secretion suggest that this peptide may be of physiologic significance as a chemical messenger involved in brain modulation of gastric secretion.
通过脑池内注射几种神经肽，评估它们对大鼠胃酸分泌的影响。蛙皮素（1微克）完全抑制胃酸分泌，减少胃液分泌量，并部分阻断胰岛素或2-脱氧-D-葡萄糖诱导的胃酸分泌刺激。该肽的抑制作用具有剂量依赖性、长效性、可逆性和特异性。蛙皮素的反应似乎是由中枢神经系统介导的；其表达不依赖于迷走神经或肾上腺，也不依赖于胃泌素分泌的减少。在测试的其他七种肽中，只有β-内啡肽和一种强效促性腺激素释放因子（促性腺激素释放素）激动剂显著降低胃酸分泌，其活性约为蛙皮素的1/100。大鼠脑中存在类蛙皮素物质以及蛙皮素抑制胃酸分泌的高效性表明，这种肽作为参与脑对胃酸分泌调节的化学信使可能具有生理意义。
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