Ulbright T M, Santa Cruz D J
Cancer. 1980 Apr 1;45(7):1646-52. doi: 10.1002/1097-0142(19800401)45:7<1646::aid-cncr2820450721>3.0.co;2-p.
A nodule, attached to the intimal surface of the external jugular vein of a 12-year-old boy, showed the light microscopic features of a pyogenic granuloma. The small muscular arteries in the adventitia contained numerous tufted intraluminal capillaries, and it is possible that the angiomatous proliferation within the jugular vein originated from the vasa vasorum, with subsequent growth into the venous lumen. This intraluminal growth dispersed the tunica elastica into the pyogenic granuloma. Ultrastructural examination showed, the lesion to be composed of capillaries lined by low and cuboidal endothelial cells, with occasional pericytes surrounded by focally multiple basal luminae. In some locations, the capillary endothelial basal lamina abutted directly on collagen with no intervening pericyte. In the stroma of the tumor there were cells with myofibroblastic features. This benign intravascular growth should be distinguished from other benign but atypical intravascular and vascular proliferations.
在一名12岁男孩的颈外静脉内膜表面附着的一个结节，呈现出化脓性肉芽肿的光镜特征。外膜中的小肌性动脉含有大量簇状管腔内毛细血管，颈静脉内的血管瘤样增生有可能起源于血管滋养管，随后长入静脉腔。这种腔内生长将弹性膜分散到化脓性肉芽肿中。超微结构检查显示，病变由低立方状内皮细胞衬里的毛细血管组成，偶尔可见周细胞被局灶性多个基底膜围绕。在某些部位，毛细血管内皮基底膜直接邻接胶原，其间无周细胞。肿瘤间质中有具有肌成纤维细胞特征的细胞。这种良性血管内生长应与其他良性但不典型的血管内和血管增生相鉴别。
