Friedman M, Kim U, Shimaoka K, Panahon A, Han T, Stutzman L
Cancer. 1980 Apr 1;45(7):1653-63. doi: 10.1002/1097-0142(19800401)45:7<1653::aid-cncr2820450722>3.0.co;2-u.
The value of aspiration cytology in the management of Hodgkin's disease is shown in this study of 228 patients and 403 aspirations; 385 from lymph nodes and 18 from extranodal masses. In all patients the initial diagnosis was established on surgical biopsy. Aspirates were helpful in staging, defining extension of unusual radiation fields, and in recognizing residual disease and relapses after therapy. Adequate material was obtained in 80% of aspirations. The diagnosis of Hodgkin's disease could not be established in the adequate cytologic sample in 9.9% of cases. In 5.5%, the diagnosis was that of benign reactive hyperplasia and in 4.4%, non-Hodgkin's lymphoma. Unsatisfactory material was usually obtained from nodes less than 1 cm in diameter or from residual lesions following radiation or chemotherapy. Only 14 of 93 such lesions proved to have active disease during follow up. There were no significant complications. Characteristics of the varied aspects of aspirated tumor cells found in Hodgkin's disease are described.
这项对228例患者和403次穿刺抽吸进行的研究显示了针吸细胞学检查在霍奇金病治疗中的价值；其中385次穿刺来自淋巴结，18次来自结外肿块。所有患者均通过手术活检确立了初始诊断。穿刺抽吸有助于分期、确定特殊放疗野的范围，以及识别治疗后的残留疾病和复发情况。80%的穿刺抽吸获得了足够的材料。在9.9%的病例中，无法在足够的细胞学样本中确立霍奇金病的诊断。在5.5%的病例中，诊断为良性反应性增生，在4.4%的病例中，诊断为非霍奇金淋巴瘤。通常从直径小于1厘米的淋巴结或放疗或化疗后的残留病变中获取不到满意的材料。在93个此类病变中，随访期间仅有14个被证明存在活动性疾病。未出现明显并发症。文中描述了在霍奇金病中发现的穿刺抽吸肿瘤细胞不同方面的特征。
