Devor E J, Buechley R W
Cancer. 1980 Apr 1;45(7):1705-12. doi: 10.1002/1097-0142(19800401)45:7<1705::aid-cncr2820450731>3.0.co;2-s.
Many studies report unusually high rates of gallbladder cancer among all American Indians and among Hispanic Americans in the Southwest and California. It has been suggested that there is a strong genetic component to the development of this cancer in American Indians and that the high rates among Hispanics are a result of genetic admixture with Indian groups. In this paper, we review the epidemiologic characteristics of gallbladder cancer in New Mexico's Hispanic population. We discuss the genetic study of the residents of the Abiquiu area of Rio Arriba County in northern New Mexico where the incidence of gallbladder cancer in white residents is significantly higher than that in any other county of the state. The Abiquiu population has a high degree of Indian ancestry, is genetically isolated, and shows close inbreeding. This combination has produced elevated frequencies of the allele or alleles predisposing to gallbladder cancer. Two familial aggregations of this disease, the first such aggregations to be reported, appear among these people.
许多研究报告称，在所有美国印第安人以及西南部和加利福尼亚州的西班牙裔美国人中，胆囊癌发病率异常高。有人认为，美国印第安人患这种癌症的过程中有很强的遗传因素，而西班牙裔美国人中高发病率是与印第安群体基因混合的结果。在本文中，我们回顾了新墨西哥州西班牙裔人群中胆囊癌的流行病学特征。我们讨论了新墨西哥州北部里奥阿比县阿比丘地区居民的基因研究，该地区白人居民的胆囊癌发病率明显高于该州其他任何县。阿比丘人群有高度的印第安血统，在基因上是隔离的，且近亲繁殖现象严重。这种情况导致了易患胆囊癌的一个或多个等位基因的频率升高。在这些人群中出现了这种疾病的两个家族聚集病例，这是首次报告的此类聚集病例。
