在雄性白色大鼠长期脱水过程中，β-肾上腺素能阻滞剂对下丘脑和神经垂体的血管升压及催产素活性的影响。
The hypothalamic and neurohypophysial vasopressor and oxytocic activities as influenced by beta-adrenergic blockade during long-term dehydration in the white male rat.
作者信息
Guzek J W, Janus J
出版信息
Endokrinologie. 1980 Jan;75(1):57-66.
Rats dehydrated up to 12 days were given intraperitoneally propranolol hydrochloride in daily dose of 1.0 mg/100 g of initial body weight. In not dehydrated animals the only dose of propranolol increased significantly the vasopressin and oxytocin release from the neurohypophysis. In dehydrated animals propranolol restrained somewhat the decrease of vasopressin in the neurohypophysis, but intensified the vasopressin depletion in the hypothalamus. The oxytocic potency of both the neurohypophysis and hypothalamus decreased progressively in animals deprived of water. Propranolol potentiated this effect of osmoreceptor stimulation.
给脱水长达12天的大鼠腹腔注射盐酸普萘洛尔，每日剂量为1.0毫克/100克初始体重。在未脱水的动物中，仅一剂普萘洛尔就能显著增加神经垂体中抗利尿激素和催产素的释放。在脱水动物中，普萘洛尔在一定程度上抑制了神经垂体中抗利尿激素的减少，但加剧了下丘脑抗利尿激素的耗竭。在缺水动物中，神经垂体和下丘脑的催产素效力都逐渐降低。普萘洛尔增强了这种渗透压感受器刺激的作用。
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