Guzek J W, Juszczak M
J Neural Transm. 1985;62(1-2):125-36. doi: 10.1007/BF01260422.
Pinealectomized, sham-operated and non operated control rats were injected intracerebroventricularly (i.c.v.) with a single dose of desmethylimipramine hydrochloride (DMI; 20 micrograms, dissolved in 10 microliters of normal saline); after 4 hours they were decapitated and the hypothalamic and neurohypophysial oxytocin content was bioassayed using the milk-ejection effect in vitro. DMI decreased oxytocin content of the hypothalamus and neurointermediate lobe in non operated and sham-operated animals. In pinealectomized rats the oxytocin content of the hypothalamus and neurointermediate lobe diminished and could be further reduced by an i.c.v. DMI injection. As shown in animals pretreated with phenoxybenzamine, these events might be only partially related to an increase of alpha-adrenergic transmission.
对松果体切除、假手术和未手术的对照大鼠进行脑室内（i.c.v.）注射单剂量盐酸去甲丙咪嗪（DMI；20微克，溶于10微升生理盐水中）；4小时后将它们断头，并用体外催乳效应生物测定下丘脑和神经垂体的催产素含量。DMI降低了未手术和假手术动物下丘脑和神经中间叶的催产素含量。在松果体切除的大鼠中，下丘脑和神经中间叶的催产素含量减少，并且脑室内注射DMI可使其进一步降低。如用酚苄明预处理的动物所示，这些事件可能仅部分与α-肾上腺素能传递增加有关。
