Rousseaux-Prévost R, Bout D, Bazin H, Capron A
Int Arch Allergy Appl Immunol. 1980;62(1):86-93.
Mice infected with Schistosoma mansoni develop a high increase of homocytotropic antibodies, thought to be involved in protection. IgE and IgG1 rise differently during the course of infection. Total serum IgE levels rise between days 20 and 30 and the maximum is observed around day 50. IgG1 levels remain almost unchanged until day 50 after which they increase dramatically, reaching a peak at day 100. S. mansoni specific IgE antibodies measured by passive cutaneous anaphylaxis parallel to variations of total IgE. On the contrary, S. mansoni specific IgG1 antibodies, also measured by passive cutaneous anaphylaxis, do not parallel total IgG1; they reach a peak between days 30 and 40 and remain high until day 100.
感染曼氏血吸虫的小鼠会产生大量亲同种细胞抗体，这些抗体被认为与免疫保护有关。在感染过程中，IgE和IgG1的升高情况有所不同。血清总IgE水平在感染后第20天至第30天之间升高，在第50天左右达到最大值。IgG1水平在第50天之前几乎保持不变，之后急剧上升，在第100天达到峰值。通过被动皮肤过敏反应测定的曼氏血吸虫特异性IgE抗体与总IgE的变化趋势平行。相反，同样通过被动皮肤过敏反应测定的曼氏血吸虫特异性IgG1抗体与总IgG1并不平行；它们在第30天至第40天之间达到峰值，并一直保持高水平直至第100天。
