Harada E, Hashimoto Y, Syuto B
Department of Physiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Comp Biochem Physiol A Physiol. 1994 Nov;109(3):667-73. doi: 10.1016/0300-9629(94)90208-9.
The effect of orally administered spermine on intestinal cessation in bovine IgG transport and digestive enzymes in the small intestine was examined in the suckling rats. By the repeated oral administration of spermine (0.1 or 0.25 mumol/g bwt) for 5 days, the ratio of protein to DNA was significantly increased. Maltase and lactase activities changed dose dependently in the spermine treated pups. Absorption of bovine IgG transport in the intestine was dose dependently depressed by spermine treatments. Morphological inspection of treated pups showed a decline in the number of epithelial cells that absorb bovine IgG and in their vesicle sizes from basal to upper regions of the villi. The ratio of mitosis in the crypt of treated pups significantly increased in the small intestine and cecum. These results suggest that exogenously administered spermine induces precocious maturation of the macromolecular transmission and disaccharidase activity in the small intestine of the suckling rats.
在乳鼠中研究了口服精胺对牛IgG在肠道转运的停止以及小肠消化酶的影响。通过连续5天重复口服精胺（0.1或0.25μmol/g体重），蛋白质与DNA的比率显著增加。在经精胺处理的幼崽中，麦芽糖酶和乳糖酶活性呈剂量依赖性变化。精胺处理使肠道中牛IgG的转运吸收呈剂量依赖性降低。对经处理幼崽的形态学检查显示，从绒毛基部到上部区域，吸收牛IgG的上皮细胞数量及其囊泡大小均有所下降。经处理幼崽小肠和盲肠隐窝中的有丝分裂比率显著增加。这些结果表明，外源性给予精胺可诱导乳鼠小肠中大分子传递和双糖酶活性的早熟成熟。
