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Ectopic secretion of complete human chorionic gonadotropin and beta-subunit by human cervical carcinoma cells lines.

作者信息

Story M T, Hussa R O

出版信息

J Clin Endocrinol Metab. 1980 Jun;50(6):1057-61. doi: 10.1210/jcem-50-6-1057.

DOI:10.1210/jcem-50-6-1057
PMID:7372785
Abstract

The CaSki and DoT cervical cancer cell lines were reported to secrete the beta-subunit of hCG in the absence of complete hCG or alpha-subunit (Science 196: 1456, 1977; J Clin Endocrinol Metab 46: 69, 1978). In the present study, concentrates of fluids from large numbers of CaSki or DoT cultures were analyzed for the presence of hCG beta and complete hCG. Although some CaSki and DoT preparations contained no detectable complete hCG, others were found to contain as much as 18% hCG. The reason for the variation in the amount of hCG relative to hCG beta in CaSki and DoT cultures is unknown.

摘要

相似文献

1
Ectopic secretion of complete human chorionic gonadotropin and beta-subunit by human cervical carcinoma cells lines.
J Clin Endocrinol Metab. 1980 Jun;50(6):1057-61. doi: 10.1210/jcem-50-6-1057.
2
A distinctive form of human chorionic gonadotropin beta-subunit-like material produced by cervical carcinoma cells.一种由宫颈癌细胞产生的独特形式的人绒毛膜促性腺激素β亚基样物质。
Cancer Res. 1986 Apr;46(4 Pt 2):1948-54.
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Differential effects of dibutyryl cyclic AMP and epidermal growth factor on the synthesis and secretion of human chorionic gonadotropin and its subunits by trophoblastic and non-trophoblastic cells.二丁酰环磷酸腺苷和表皮生长因子对滋养层细胞和非滋养层细胞合成及分泌人绒毛膜促性腺激素及其亚基的不同作用。
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Use of glycosidase digested human chorionic gonadotropin beta-subunit to explain the partial binding of ectopic glycoprotein hormones to Con A.使用糖苷酶消化的人绒毛膜促性腺激素β亚基来解释异位糖蛋白激素与伴刀豆球蛋白A的部分结合。
Endocrinology. 1981 Dec;109(6):2276-8. doi: 10.1210/endo-109-6-2276.

引用本文的文献

1
Effect of media composition on the induction of chorionic gonadotropin by sodium butyrate in HeLa cells.培养基成分对丁酸钠诱导HeLa细胞产生绒毛膜促性腺激素的影响。
In Vitro. 1983 Jan;19(1):1-6. doi: 10.1007/BF02617987.