Santilli J, Potsus R L, Goodfriend L, Marsh D G
J Allergy Clin Immunol. 1980 Jun;65(6):406-12. doi: 10.1016/0091-6749(80)90232-8.
Five hundred twenty-five atopic patients were skin tested over a 12-mo period to several crude allergens with a puncture skin-testing technique utilizing a bifurcated needle originally developed for smallpox immunization. Of these, 122 were highly allergic to short ragweed pollen and were subsequently tested with a series of purified grass and ragweed allergens. Data of their reactivity to these allergens is presented, and the phenomenon that each patient has a unique "allergic fingerprint" to purified pollen allergens is shown. The puncture technique showed good correlation with quantitative intradermal skin titration and offered a definite advantage, because many allergens could be rapidly and accurately assayed with good patient compliance.
在12个月的时间里，采用最初为天花免疫开发的叉形针，运用点刺皮肤试验技术，对525名特应性患者进行了几种粗制过敏原的皮肤试验。其中，122人对短豚草花粉高度过敏，随后用一系列纯化的草和豚草过敏原进行了检测。展示了他们对这些过敏原的反应性数据，并显示出每位患者对纯化花粉过敏原都有独特的“过敏指纹”这一现象。点刺技术与定量皮内皮肤滴定显示出良好的相关性，并且具有明显优势，因为许多过敏原可以快速、准确地检测，患者的依从性也很好。
