Dau P C, Yano C S, Ettinger S J
Neurology. 1979 Jul;29(7):1065-8. doi: 10.1212/wnl.29.7.1065.
Anti-acetylcholine receptor (AChR) antibody (ab) was found in the serum of a dog with acute myasthenia gravis (MG) by the use of Cowan 1 strain Staphylococcus aureus to bind radiolabeled anti-AChR ab-AChR immune complexes. Fifteen months later, when the dog was in remission, there was only a very low level of the anti-AChR ab. These observations strengthen the contention that anti-AChR ab is important in the pathophysiology of myasthenia gravis. Higher titers of the canine ab were measured with rabbit than with human AChR, whereas 17 human MG sera, selected to represent a wide range of anti-AChR ab titers, were all more reactive with human AChR. The degree of cross-reactivity of human anti-AChR ab with rabbit AChR varied widely, indicating a heterogeneous population of anti-AChR ab molecules in human myasthenia gravis sera.
通过使用考恩1株金黄色葡萄球菌结合放射性标记的抗乙酰胆碱受体（AChR）抗体-AChR免疫复合物，在一只患有急性重症肌无力（MG）的犬血清中发现了抗AChR抗体（ab）。15个月后，当这只犬处于缓解期时，抗AChR抗体水平极低。这些观察结果支持了抗AChR抗体在重症肌无力病理生理学中起重要作用的观点。用兔AChR检测到的犬抗体滴度高于用人AChR检测到的滴度，而选择的17份人MG血清代表了广泛的抗AChR抗体滴度范围，它们与人AChR的反应性都更强。人抗AChR抗体与兔AChR的交叉反应程度差异很大，表明人重症肌无力血清中的抗AChR抗体分子群体具有异质性。
