甲氧氯普胺对偏头痛中泡腾阿司匹林吸收的影响。
The effect of metoclopramide on the absorption of effervescent aspirin in migraine.
作者信息
Volans G N
出版信息
Br J Clin Pharmacol. 1975 Feb;2(1):57-63. doi: 10.1111/j.1365-2125.1975.tb00472.x.
1 The absorption of effervescent aspirin was studied in two groups of patients during attacks of migraine. The first group received effervescent aspirin alone whilst the second group received intramuscular metoclopramide before effervescent aspirin. 2 After effervescent aspirin alone there was significant impairment in the rate of aspirin absorption during migraine attacks compared with the rate of aspirin absorption in normal volunteers and in the same patients when headache-free. 3 When metoclopramide was given before effervescent aspirin the rate of aspirin absorption during migraine attacks was not significantly different from that obtained in normal volunteers given effervescent aspirin alone or from that obtained in the patients themselves when given both metoclopramide and effervescent aspirin when headache-free. 4 It is concluded that the impairment of absorption of effervescent aspirin during migraine attacks is related to impaired gastro-intestinal motility with delayed gastric emptying and that this impaired motility can be overcome by parenteral metoclopramide.
在两组偏头痛发作的患者中研究了泡腾阿司匹林的吸收情况。第一组仅服用泡腾阿司匹林，而第二组在服用泡腾阿司匹林前先接受了肌肉注射甲氧氯普胺。
与正常志愿者以及同一患者在无头痛时的阿司匹林吸收速率相比，单独服用泡腾阿司匹林后，偏头痛发作期间阿司匹林的吸收速率明显受损。
在服用泡腾阿司匹林前给予甲氧氯普胺时，偏头痛发作期间阿司匹林的吸收速率与单独给予泡腾阿司匹林的正常志愿者的吸收速率没有显著差异，也与同一患者在无头痛时同时给予甲氧氯普胺和泡腾阿司匹林时的吸收速率没有显著差异。
得出的结论是，偏头痛发作期间泡腾阿司匹林吸收受损与胃肠动力受损、胃排空延迟有关，并且这种动力受损可以通过胃肠外给予甲氧氯普胺来克服。
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