Volans G N
Br Med J. 1974 Nov 2;4(5939):265-8. doi: 10.1136/bmj.4.5939.265.
The absorption of effervescent aspirin was studied in 42 patients during acute attacks of migraine. When compared with normal controls and with themselves between attacks 19 out of the 42 patients showed impairment of absorption. Impairment of absorption seemed to correlate with the severity of the headache and the gastro-intestinal symptoms at the time of treatment but not with the duration of the attack or with the type of migraine. This study probably underestimated the prevalence of impairment of absorption in migraine attacks, and it is concluded that the treatment of acute migraine symptoms by oral drugs should use those formulations which are rapidly absorbed under normal conditions.
在42例偏头痛急性发作患者中研究了泡腾阿司匹林的吸收情况。与正常对照组以及发作间期的自身情况相比，42例患者中有19例出现吸收障碍。吸收障碍似乎与治疗时头痛的严重程度和胃肠道症状相关，但与发作持续时间或偏头痛类型无关。本研究可能低估了偏头痛发作时吸收障碍的发生率，得出的结论是，口服药物治疗急性偏头痛症状时应选用在正常情况下能快速吸收的制剂。
