Cerklewski F L
J Nutr. 1981 Oct;111(10):1780-3. doi: 10.1093/jn/111.10.1780.
The main objective of this study was to determine the relationship between zinc content of teeth and susceptibility to dental caries. Pregnant albino rats were fed a purified diet containing 8, 15 or 30 ppm zinc throughout gestation and lactation. Food intake of all rats was restricted to that consumed by the lowest zinc group. At day 20 of lactation, pups were weaned to a high sucrose, caries-promoting diet and orally innoculated with streptococcus mutans. Dams consuming the lowest zinc-containing diet exhibited a mild zinc deficiency as evidenced by reductions in gestational weight gain and zinc content of milk, serum and tibia when compared to other groups. All offspring survived. Pups originating from the lowest zinc group had significantly less zinc in molar enamel and dentin fractions compared to other groups at the end of a 30-day caries test period, but tibia zinc was essentially equal. This apparent pre-eruptive reduction in zinc content of enamel and dentin of offspring was associated with significantly greater dental caries score on the buccal surface. This suggests that moderate dietary zinc deficiency is sufficient to reduce the pre-eruptive zinc content of both enamel and dentin and to increase dental caries.
本研究的主要目的是确定牙齿锌含量与龋齿易感性之间的关系。在整个妊娠期和哺乳期，给怀孕的白化大鼠喂食含8、15或30 ppm锌的纯化日粮。所有大鼠的食物摄入量限制在锌含量最低组所消耗的量。在哺乳期第20天，将幼崽断奶，喂食高蔗糖、易致龋的日粮，并经口接种变形链球菌。与其他组相比，食用含锌量最低日粮的母鼠表现出轻度锌缺乏，这可从妊娠期体重增加以及乳汁、血清和胫骨中的锌含量降低得到证明。所有后代均存活。在30天的龋齿试验期结束时，与其他组相比，来自锌含量最低组的幼崽磨牙牙釉质和牙本质部分的锌含量明显更低，但胫骨锌含量基本相等。后代牙釉质和牙本质中锌含量这种明显的萌出前降低与颊面龋齿得分显著更高有关。这表明适度的膳食锌缺乏足以降低牙釉质和牙本质萌出前的锌含量并增加龋齿发生率。
