Matsui F, Robertson D L, Poirier M A, Lovering E G
J Pharm Sci. 1980 Apr;69(4):469-71. doi: 10.1002/jps.2600690430.
Two previously reported but unidentified phenylburazone degradation products were isolated from a tablet that was stored at 60 degrees for 203 days. The compounds, alpha-(N-phenylcarbamoyl)-N-caproylhydrazobenzene and alpha-hydroxy-alpha-(N-phenylcarbamoyl)-N-caproylhydrazobenzene, were isolated by chromatography, identified by mass and NMR spectrometry, and synthesized by the reaction of aniline with phenylbutazone or its hydroxy analog, respectively.
从一片在60摄氏度下储存203天的药片上分离出了两种先前已报道但未鉴定的苯基布他松降解产物。通过色谱法分离出了化合物α-(N-苯基氨基甲酰基)-N-己酰基氢化偶氮苯和α-羟基-α-(N-苯基氨基甲酰基)-N-己酰基氢化偶氮苯，通过质谱和核磁共振光谱法进行了鉴定，并分别通过苯胺与苯基布他松或其羟基类似物的反应进行了合成。
