Richter J A, Runge L A, Pinals R S, Oates R P
J Rheumatol. 1980 Mar-Apr;7(2):153-9.
Life table analysis was used to determine the incidence of treatment termination in rheumatoid arthritis patients after initial therapeutic courses of gold (93) and antimalarial compounds (101). Patients treated with antimalarial compounds tended to terminate treatment sooner than those receiving gold. The most common reasons for discontinuing antimalarial therapy were lack of initial benefit and loss of response to the drug. Clinical and laboratory characteristics of patients at onset of therapy did not influence failure rates to a great extent.
生存分析用于确定类风湿性关节炎患者在接受金制剂（93例）和抗疟化合物（101例）初始治疗疗程后的治疗终止发生率。接受抗疟化合物治疗的患者比接受金制剂治疗的患者更早终止治疗。停止抗疟治疗的最常见原因是初始治疗无效和对药物反应丧失。治疗开始时患者的临床和实验室特征在很大程度上并未影响失败率。
