Sambrook P N, Browne C D, Champion G D, Day R O, Vallance J B, Warwick N
J Rheumatol. 1982 Nov-Dec;9(6):932-4.
Treatment terminations with gold sodium thiomalate (GST) in 200 patients with rheumatoid arthritis (RA) were analyzed using the life table method. The termination rate was 27% at 6 months, 48% at 12 months and 84% at 48 months. The major reason for termination was mucocutaneous reaction. Pretreatment clinical and laboratory status of the RA did not influence terminations significantly. Concurrent administration of oral corticosteroids had no significant effect on gold terminations. Complete control of synovitis was achieved in 38% of patients by a median time of 6 months but sustained for greater than 12 months in only 19%.
采用寿命表法分析了200例类风湿关节炎（RA）患者使用硫代苹果酸金钠（GST）治疗的终止情况。6个月时终止率为27%，12个月时为48%，48个月时为84%。终止治疗的主要原因是皮肤黏膜反应。RA治疗前的临床和实验室状况对终止治疗无显著影响。同时服用口服糖皮质激素对金制剂治疗的终止无显著影响。38%的患者在中位时间6个月时实现了滑膜炎的完全控制，但仅19%的患者持续超过12个月。
