[Antithrombin III level on the intravenous injection of tissue thromboplastin and heparin to rats with depressed blood anticoagulating system function due to an atherogenic diet].

Rats with depressed function of the blood anticoagulation system due to an atherogenic diet had a slightly reduced level of antithrombin III by the sixth month of the diet as compared to the indices of control animals. Intravenous injection of tissue thromboplastin revealed delayed and incomplete binding of thrombin by antithrombin III in the experimental animals, which was characterized by only an insignificant decrease in the level of the inhibitor as compared to its change in control animals kept under similar experimental conditions. Preliminary intravenous injection of small doses of heparin into animals with depressed function of the anticoagulation system and low level of heparin in blood stimulates and promotes the binding of thrombin by antithrombin III under conditions of increased thrombinogenesis following intravenous injection of tissue thromboplastin.