Liapina L A, Bazaz'ian G G
Vopr Med Khim. 1981 Jan-Feb;27(1):115-20.
Within 10 min after single intravenous administration of the heparin-thromboplastin complex into animals, kept on natural and atherogenic diets, the total fibrinolytic activity and the non-enzymatic fibrinolysis were increased in blood plasma, which maintained within 60 min after the complex administration. Within 90 min of the experiment the non-enzymatic fibrinolysis was decreased in blood plasma of both groups and the activity reached the initial level within 120 min after the treatment. The increase in the total and non-enzymatic fibrinolysis was distinctly higher in controls as compared with animals kept on atherogenic diet. Within 60 min after administration of the heparin-thromboplastin complex physiological solvents of the unstabilized fibrin were found in liver and lung tissues of control animals as well as in lung and heart tissues of animals kept on the atherogenic diet.
给食用天然饮食和致动脉粥样硬化饮食的动物单次静脉注射肝素 - 凝血活酶复合物后10分钟内，血浆中的总纤溶活性和非酶纤溶作用增强，且在复合物注射后60分钟内保持这一状态。实验90分钟内，两组动物血浆中的非酶纤溶作用均降低，且在治疗后120分钟内活性恢复至初始水平。与食用致动脉粥样硬化饮食的动物相比，对照组动物的总纤溶和非酶纤溶作用增强更为明显。在注射肝素 - 凝血活酶复合物60分钟后，在对照组动物的肝脏和肺组织以及食用致动脉粥样硬化饮食动物的肺和心脏组织中发现了不稳定纤维蛋白的生理溶剂。
