Huhn D, Meister P, Wilmanns W
Klin Wochenschr. 1980 Jan 2;58(1):31-5. doi: 10.1007/BF01477141.
Diagnosis of malignant histiocytosis (MH) was confirmed in 16 patients. Stage at diagnosis was I-II in nine, and III-IV in seven patients. Porr prognosis and "B",-symptoms were correlated to advanced stages. Bone marrow biopsy proved most useful to verify organ involvement. Scintigraphy and computerized tomography, too, detected organ involvement in some patients and were helpful for judging response to therapy. Relapses after radiotherapy were frequent. Polychemotherapy using "CHOP"-combination is recommended for most patients and may in stages I-II be supplemented by primary or secondary involved or extended field irradiation and in more advanced stages by mainbulk-irradiation. The value of prophylactic CNS-therapy remains controversial. Pathophysiological aspects and differential diagnosis are discussed.
16例患者确诊为恶性组织细胞增多症（MH）。确诊时I-II期9例，III-IV期7例。预后不良和“B”症状与晚期相关。骨髓活检对证实器官受累最有用。闪烁扫描和计算机断层扫描在一些患者中也检测到了器官受累，有助于判断治疗反应。放疗后复发频繁。大多数患者推荐使用“CHOP”联合化疗，I-II期可辅以原发或继发受累野或扩大野照射，更晚期则采用主体照射。预防性中枢神经系统治疗的价值仍存在争议。本文讨论了病理生理方面和鉴别诊断。
