Kibe A, Wake C, Kuramoto T, Hoshita T
Lipids. 1980 Apr;15(4):224-9. doi: 10.1007/BF02535831.
The effect of oral administration of taurine (200-300 mg daily) on the metabolism of bile acids was studied in male guinea pigs which have predominantly glycine conjugated bile acids. The results were summarized as follows: (a) oral administration of taurine for 10 days increased taurine-conjugated bile acids and the ratio of glycine- to taurine-conjugated bile acids (G:T ratio) shifted from 3.95 to 0.19; (b) in taurine fed guinea pigs, the half-life of chenodeoxycholic acid (CDC) was about 40% shorter than that in controls and the fractional turnover rate increased by 70%; (c) the synthetic rate (mg/day/500 g body weight) of bile acids increased from 4.28 to 7.27 by taurine feeding; (d) hepatic cholesterol 7 alpha-hydroxylase activity was increased 2.4-fold by taurine feeding; (e) the total pool size of bile acids did not change significantly but the amount of lithocholic acid in the caecum and large intestine increased by about 40%; (f) neither free cholesterol nor cholesterol ester levels in liver and serum changed significantly. Results of this study suggest that changing the G:T ratio in the bile acid conjugation pattern may influence the rate of hepatic bile acid synthesis.
在主要含有甘氨酸结合型胆汁酸的雄性豚鼠中，研究了口服牛磺酸（每日200 - 300毫克）对胆汁酸代谢的影响。结果总结如下：(a) 口服牛磺酸10天可增加牛磺酸结合型胆汁酸，甘氨酸与牛磺酸结合型胆汁酸的比例（G:T比例）从3.95变为0.19；(b) 在喂食牛磺酸的豚鼠中，鹅去氧胆酸（CDC）的半衰期比对照组短约40%，分数周转率增加了70%；(c) 喂食牛磺酸使胆汁酸的合成速率（毫克/天/500克体重）从4.28增加到7.27；(d) 喂食牛磺酸使肝脏胆固醇7α-羟化酶活性增加了2.4倍；(e) 胆汁酸的总池大小没有显著变化，但盲肠和大肠中石胆酸的量增加了约40%；(f) 肝脏和血清中的游离胆固醇及胆固醇酯水平均无显著变化。本研究结果表明，改变胆汁酸结合模式中的G:T比例可能会影响肝脏胆汁酸的合成速率。
